Introduction
UniBind is a database of direct interactions between transcription factors (TFs) and DNA across nine species, hosted by the University of Oslo and ELIXIR Norway. The portal provides a comprehensive map of transcription factor binding sites (TFBSs) derived from uniform processing of thousands of ChIP-seq datasets using the ChIP-eat software.
Datasets in UniBind are separated into robust and permissive collections based on two quality control metrics: similarity of the DAMO-optimized TF binding motif to the expected canonical motif, and enrichment of TFBSs around ChIP-seq peak summits. Datasets satisfying both criteria are classified as robust; the remainder as permissive.
Key Features
- Nine species — TF binding site data across human, mouse, rat, and six other species
- Thousands of ChIP-seq datasets — uniformly processed for consistency and comparability
- Robust and permissive collections — quality-tiered datasets so users can choose the confidence level appropriate for their analysis
- High-confidence predictions — binding site calls validated against canonical motifs and peak summit enrichment
- ChIP-eat pipeline — standardized processing ensures reproducibility across all datasets
- Open access — all data freely available through the web portal and for bulk download
Getting Started
- Visit UniBind to browse available species and transcription factors
- Select a species and TF of interest to view binding site predictions
- Choose between robust and permissive collections based on your confidence requirements
- Download datasets for integration with your own genomic analyses